Hi Diane,
I don't know if you've experimented much with digital desks which IP audio, but the AXIA Livewire audio works fine in Audition 3 on Win 7x64 and all Zetta/RCS products. I know it's not Simian, but as with all radio software you can assign various bits of audio to go through various channels/ports on the card. If it has a Windows driver, then chances are Audition CC will probably work. Just my two cents. I know it's not related to a specific brand, but as IP audio/digital desks are the way of the future, you may wish to take that in to consideration too. I know IP audio is a completely different ball game, but you can have 16 virtual channels available to push audio through and around your network.
Anyway, In my experience with Audition 3 vs CC, (and I've used both on mac and PC in radio stations), if you don't need to upgrade, I would probably still say stick with Audition 3. It will do the same job.
cheers
Steve